I think Will Beemer used a Larsen system on his home (or was it a Heartwood project?)
Does the Larsen truss offer any shear transfer from the frame? Often in the work I do we rely on the SIPs or the wall system to take wind load / shear.
A friend is entertaining a double offset 2x framing. 2x10 plate and sill and 2x4 studs will be offset except @ windows / doors, which will be framed with 2x10. It will be filled with wet cellulose and possibly have Hi-R 1 1/2" foam on the exterior, over sheathing. Rain screen / strapping over the foam for siding. This doesn't solve the shear issue unless we get creative - but for his needs it will work.