Yellow poplar was used in covered bridges in Indiana, Ohio (that I have observed) and reportedly elsewhere as well. Research on yellow poplar mortise and tenon joints was conducted at the University of Wyoming to fairly good results. So strength wise, it is suitable for a frame, and certainly it is easy enough to work. However, it dries REALLy fast, and usually results in heavy checking and winding timbers. Good end grain sealer will help, BUT, still expect some material degradation with drying. Also, good dark yellow heartwood is noticably more stable than the white sapwood.
The Timber Frame Joinery and Design Workbook (sold at the Guild on-line store) is a good place to start sizing posts and beams, if you are interested in doing it yourself. The Resource Guide has some engineers listed which should be able to help, especially if you need stamped documents.