We use 2x8 "spacers" for the second floor.
1x6 T&G, then the 2X8 on top of that, then whatever floor finish you want on the second floor.
Allows for can lighting, duct work, long run grey water pipes etc. Just need a couple of 2X6 vertical walls to get up and down somewhere or a chaise inside of a closet wall works well for duct work.